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Not All Dietary Fiber Is Created Equal

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THURSDAY, April 28, 2022 (HealthDay News) — Dietary fiber will get numerous reward for serving to folks really feel full and for reducing the chance of sure varieties of illness.

Yet many varieties of dietary fiber exist — and so they don’t all work the identical, in accordance with a small new examine.

“When you actually get down to it, fiber is incredibly heterogeneous. It’s very, very different,” mentioned examine co-author Michael Snyder, a professor and chair of genetics at Stanford University School of Medicine. “It’s like saying all animals are the same.”

His staff centered on two fashionable fiber dietary supplements to see how they affected ldl cholesterol and blood sugar. Most people get too little fiber in their diet, and dietary supplements may probably shut this hole, the researchers mentioned in background notes.

Arabinoxylan is a grain fiber present in frequent dietary supplements comparable to Metamucil and psyllium husk. Inulin is discovered naturally in fruit and veggies comparable to bananas and asparagus.

“It’s very, very clear arabinoxylan overall does reduce cholesterol,” mentioned Snyder.

The different fiber, inulin, didn’t work for reducing ldl cholesterol in most members, however did set off irritation and in some greater doses led to a spike in a marker for liver injury.

Neither lowered blood sugar.

“People do still respond differently,” Snyder mentioned. “There are some people that didn’t respond to arabinoxylan, but, ironically, they did lower their cholesterol with inulin. There’s at least one participant who did that.”

The examine included 18 wholesome people who volunteered for 3 periods, every three weeks lengthy. For one session, members took 10 grams every day of both chicory inulin or arabinoxylan for per week, then 20 grams every day for per week and 30 grams every day for per week.

The volunteers then took six to eight weeks off, once they ate what they often would. When they returned, they adopted the identical protocol however for the opposite complement.

During the third session, they took a complement containing 5 varieties of fiber that included inulin and arabinoxylan.

The members logged their meals and offered samples of their blood, urine and stool.

The researchers measured exercise ranges of intestine micro organism, genes, proteins and lipids. The effort was meant to get a readout of all metabolic and microbiological results of the fiber.

The analysis staff discovered essentially the most variation in measurements associated to intestine micro organism. Some of these micro organism elevated when extra arabinoxylan was eaten and a few decreased, and a few elevated no matter what quantity of arabinoxylan was consumed. All the examined dietary supplements shifted the composition of a participant’s microbiome (the gathering of microbes residing within the physique), in accordance with the analysis.

Many of the members who consumed greater ranges of arabinoxylan had a drop in LDL ldl cholesterol, the “bad” ldl cholesterol. Those taking a combined complement additionally had a drop, however not by as a lot.

During the examine, researchers additionally discovered that the mechanism by which arabinoxylan removes ldl cholesterol from the physique was not by means of binding, as beforehand suspected, however somewhat by changing it to bile acids, Snyder mentioned.

“We’ve come out with a whole new mechanism for how cholesterol is probably reduced and it involves your microbiome as well,” Snyder mentioned.

While arabinoxylan diminished LDL ldl cholesterol for a lot of the members, some skilled a smaller lower. The researchers assume there could a hyperlink to protein consumption.

In the inulin analysis, researchers discovered a spike in irritation in most individuals on the highest dose, and the liver injury marker in three people. Yet, in a single individual, the excessive dose of inulin decreased inflammation.

Snyder mentioned one of many most important examine takeaways is that members responded in a different way.

“You shouldn’t just assume, ‘I’m going to take this, it’s going to work.’ I think you should take this and say, ‘Now, did it work on me?’” Snyder mentioned.

The staff is constant to check arabinoxylan and inulin, in addition to two extra varieties of fiber.

“That’s where it is right now, but there’s no question we should be able to get predictive about this,” Snyder mentioned. “We’re not there yet.”

The findings have been printed April 28 in Cell Host & Microbe.

Dr. Natalie Bello directs hypertension analysis on the Smidt Heart Institute at Cedars-Sinai in Los Angeles.

That some people had a response reverse to that of many within the examine “hammers home the need for individualized treatment strategies,” mentioned Bello, who was not concerned within the examine.

“Our understanding of the interaction between dietary components and the microbiome is in its infancy so future work examining dietary patterns and fiber supplementation will be helpful,” Bello mentioned.

Prior information has proven advantages related to greater dietary fiber consumption and decrease blood strain, Bello mentioned, however a high-fiber weight-reduction plan isn’t for everybody.

“A healthy diet along with regular exercise, adequate sleep and blood pressure, blood sugar and cholesterol control are the mainstays of improving heart health,” Bello mentioned. Diets related to enhancements in fat referred to as lipids embody DASH, vegetarian and Mediterranean, she added.

More info

The U.S. Centers for Disease Control and Prevention has extra on preventing high cholesterol.

SOURCES: Michael Snyder, PhD, professor and chair, genetics, Stanford University School of Medicine, Stanford, Calif.; Natalie Ann Bello, MD, MPH, director, hypertension analysis, Smidt Heart Institute, Cedars-Sinai, Los Angeles; Cell Host & Microbe, April 28, 2022


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